12/18/2023 0 Comments High mpv and high cholesterolThe cohort was part of a population-based, prospective, observational, single-center study in western mid-Germany conceptualized primarily for studying cardiovascular disease. MPV was determined in 15 010 participants enrolled in the GHS between April 2007 and April 2012 at their baseline examination. 15 Furthermore, higher MPV implied an increased risk of vascular mortality, particularly of ischemic heart disease, in a large population study. 14 Patients with preexisting coronary artery disease and increased MPV are at higher risk of myocardial infarction (MI). 3-5 Higher MPV was shown to be associated with traditional cardiovascular risk factors 6 such as hypertension, 7 diabetes, 8 obesity, 9 hypercholesterolemia, 10 and smoking 11 and is correlated with an increased risk for both arterial 12, 13 and venous thrombosis. 2 Larger platelets are metabolically and enzymatically more active and have higher thrombotic potential and higher expression of platelet surface activation markers. In addition, changes in platelet volume may also occur at the sites of activation with changes in platelet shape. Several cytokines and growth factors may affect megakaryocytopoiesis and release of larger platelets. 1 Mean platelet volume (MPV), a measure of platelet size, is a potential biological marker of platelet function and is commonly available in the clinical practice at relatively low cost. Platelets play a key role in both hemostasis and thrombosis and, according to recent findings, in inflammation, atherogenesis, and cancer metastasis. The observed interactions between genetic variability, CVRFs, and MPV and its association with the development of cardiovascular disease or thrombotic risk need to be further investigated. This study provides evidence for heterogeneity in the profile of determinants for MPV between sexes. The curves of cumulative mortality, stratified for sex, showed worse survival for males only with MPV >9.96 fL vs MPV ≤9.96 fL ( P <. The full model, including age, CVRFs, laboratory parameters, medications, and genetic variation, explained 20.4% of the MPV variance in females and 18.6% in males. Seven single nucleotide polymorphisms (SNPs) for females and 4 SNPs for males were associated with higher MPV. Intake of oral contraceptives (β, 0.150 95% CI, 0.0649 to 0.236) and menstruation (β, 0.123 95% CI, 0.0231 to 0.224) were strongly associated with higher MPV in females. Genetic information was available for 4175 individuals. MPV has been evaluated in 15 010 individuals from the population-based Gutenberg Health Study. To date, a comprehensive analysis including known genetic and nongenetic factors that determine MPV is still lacking. Mean platelet volume (MPV), a measure of platelet size, is a potential biological marker of platelet function.
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